Machine learning may help in early identification of severe sepsis

IMAGE: This is an early identification of sepsis.
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Credit: ATS

ATS 2017, WASHINGTON, DC — A machine-learning algorithm has the capability to identify hospitalized patients at risk for severe sepsis and septic shock using data from electronic health records (EHRs), according to a study presented at the 2017 American Thoracic Society International Conference. Sepsis is an extreme systemic response to infection, which can be life-threatening in its advanced stages of severe sepsis and septic shock, if left untreated.

“We have developed and validated the first machine-learning algorithm to predict severe sepsis and septic shock in a large academic multi-hospital healthcare system,” said lead author Heather Giannini, MD, of the Hospital of the University of Pennsylvania. “This is a breakthrough in the use of machine learning technology, and could change the paradigm in early intervention in sepsis.”

Machine learning is a type of artificial intelligence that provides computers with the ability to learn complex patterns in data without being explicitly programmed, unlike simpler rule-based systems. Earlier studies have used electronic health record data to trigger alerts to detect clinical deterioration in general.

The researchers developed a machine-learning algorithm to predict patients most at risk for severe sepsis or septic shock, and to use their electronic health record to alert the care team. To develop the algorithm, they trained a random forest classifier, an approach to classify a wide range of data, to sort through electronic health record data for 162,212 patients discharged between July 2011 and June 2014 from three University of Pennsylvania Health System acute care hospitals. The algorithm was able to examine hundreds of variables on a continuous basis. Patients with severe sepsis or septic shock were labeled as such 12 hours before the actual onset of severe sepsis or septic shock. The onset was determined…

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